What Are The Specific Polyphenolic Compounds Present In The Anthocyanin-rich Extract Of Aronia Berries That Have Been Shown To Modulate The Gut-brain Axis And Downregulate The NF-κB Signaling Pathway, Potentially Providing Therapeutic Benefits For Individuals With Hashimoto's Thyroiditis?
The anthocyanin-rich extract of aronia berries contains several polyphenolic compounds that may modulate the gut-brain axis and downregulate the NF-κB signaling pathway, potentially benefiting individuals with Hashimoto's thyroiditis. These compounds include:
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Anthocyanins: Specifically, cyanidin-3-glucoside, delphinidin-3-glucoside, petunidin-3-glucoside, peonidin-3-glucoside, and malvidin-3-glucoside. These are the main pigments responsible for the health benefits associated with aronia berries.
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Other Polyphenols:
- Quercetin: A flavonoid with anti-inflammatory properties.
- Chlorogenic Acid: A phenolic acid known for its antioxidant effects.
- Ellagic Acid: Recognized for its antioxidant and potential anti-cancer properties.
- Resveratrol: A stilbene with various health benefits, including anti-inflammatory effects.
These compounds may work synergistically to modulate the gut-brain axis by improving gut microbiota, enhancing the gut barrier, and producing metabolites that influence brain function. They also downregulate the NF-κB pathway, reducing inflammation and potentially alleviating autoimmune conditions like Hashimoto's thyroiditis by decreasing pro-inflammatory cytokines.